“Giants in a Microcosm”

“Giants in a Microcosm”

On examination of a breast mass surgically excised in a 69-years-old woman, a pure invasive micropapillary carcinoma (MPC) was diagnosed (Figure 1). At close examination, intensely eosinophilic syncytial-multinucleated giant cells (CD68+) percolating the stromal bands were identified (Figure 1). The breast carcinoma illustrated here shows therefore a combination of 2 rarities, namely, an invasi...

Man Is a Microcosm

Origin of life in a digital microcosm

While all organisms on Earth share a common descent, there is no consensus on whether the origin of the ancestral self-replicator was a one-off event or whether it only represented the final survivor of multiple origins. Here, we use the digital evolution system Avida to study the origin of self-replicating computer programs. By using a computational system, we avoid many of the uncertainties i...

Coalgebraic Components in a Many-Sorted Microcosm

The microcosm principle, advocated by Baez and Dolan and formalized for Lawvere theories lately by three of the authors, has been applied to coalgebras in order to describe compositional behavior systematically. Here we further illustrate the usefulness of the approach by extending it to a many-sorted setting. Then we can show that the coalgebraic component calculi of Barbosa are examples, with...

Green Driver: AI in a Microcosm

The Green Driver app is a dynamic routing application for GPS-enabled smartphones. Green Driver combines client GPS data with real-time traffic light information provided by cities to determine optimal routes in response to driver route requests. Routes are optimized with respect to travel time, with the intention of saving the driver both time and fuel, and rerouting can occur if warranted. Du...